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Prasad S. Dalvi

  • Assistant Professor
    Biology Department

Courses Taught

Anatomy and Physiology (BIOL 108)

Anatomy and Physiology Laboratory (BIOL 109)

Human Gross Anatomy (BIOL 365)

Human Gross Anatomy Laboratory (BIOL 366)

Molecular and Cellular Biology Laboratory (BIOL 123)

 

Educational History

Ph.D. (Physiology), Faculty of Medicine, University of Toronto, Canada
Doctoral Thesis Research: Molecular mechanisms involved in insulin- and leptin-mediated regulation of hypothalamic proglucagon gene expression and the action of glucagon-like peptides on hypothalamic neuropeptides

M.D. (Physician), Donetsk State Medical Institute/University, Donetsk, Ukraine

Professional Experience

Assistant Professor, Department of Biology, Gannon University, Erie, PA (2017- present)

Assistant Professor (Physiology), Lake Erie College of Osteopathic Medicine, Bradenton, Florida, USA (2017)
           
Lecturer (Anatomy and Physiology), Faculty of Life Sciences, School of Medical Sciences, University of Bradford, Bradford, UK (2016 - 2017)

Sessional (Adjunct) Lecturer (Physiology), Department of Physiology, Faculty of Medicine, University of Toronto, Canada (2015 - 2016)

Visiting Faculty Member, Dr. D. Y. Patil University, Biotechnology and Bioinformatics Institute, Pune, India (2014)

Postdoctoral Research Fellow, Division of Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, Canada / Department of Physiology, Faculty of Medicine, University of Toronto, Canada (2012 - 2015)

Research Assistant Professor, Toxicology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, USA (2001 - 2006)

General Practitioner / Family Physician, Government and Private Hospitals/Clinics, District Sindhudurg, Maharashtra, India (1995 - 2000)

Professional Societies

American Physiological Society, USA

British Society for Neuroendocrinology, UK

Medical Council of India

Publications

  1. Dalvi PS, Yang S, Swain N, Saha S, Bourdon C, Zhang L, Chami R, and Bandsma RH (2018) Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction. PLoS ONE 13(7): e0199916
  2. Dalvi PS, Chalmers JA, Luo V, Han DY, Wellhauser L, Liu Y, Tran DQ, Castel J, Luquet S, Wheeler MB, Belsham DD (2017) High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons. Int J Obes (Lond) 41:149-158
  3. Guo J, Pereira TJ, Dalvi P, Yeung LS, Swain N, Breen DM, Lam L, Dolinsky VW, Giacca A (2017) High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis. Metabolism 68:108-118
  4. Treen AK, Luo V, Chalmers JA, Dalvi PS, Tran D, Ye W, Kim GL, Friedman Z, Belsham DD  (2016) Divergent regulation of ER and Kiss genes by 17β-estradiol in hypothalamic ARC versus AVPV models. Molecular Endocrinology 30:217-33
  5. Kvissberg MA, Dalvi PS, Kerac M, Voskuijl W, Berkley JA, Priebe MG, Bandsma RH (2016) Carbohydrate malabsorption in acutely malnourished children and infants: A systematic review. Nutrition Reviews 74:48-58
  6. Guo J, Breen DM, Dalvi PS, Pereira TJ, Zhang H, Mori Y, Ghanim H, Tumiati L; Fantus IG; Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer S, Giacca A (2015) The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent. Atherosclerosis 241:111-20
  7. Purser MJ*, Dalvi PS*, Wang ZC, Belsham DD (2013) The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo. PLoS One 8(4):e61616 (* Contributed equally)
  8. Dalvi PS, Dalvi RR, Billups LH (2013) Potentiation of the hepatic toxicity of carbon disulfide by chlordane. Toxicology International 20:132-37
  9. Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD (2012) Direct Regulation of the Proglucagon Gene by Insulin, Leptin and cAMP in Embryonic versus Adult Hypothalamic Neurons. Molecular Endocrinology 26:1339-55
  10. Dalvi PS, Belsham DD (2012) Glucagon-Like Peptide-2 Directly Regulates Hypothalamic Neurons Expressing Neuropeptides Linked to Appetite Control in Vivo and in Vitro. Endocrinology 153:2385-97 (This article was selected by the Endocrine Society, USA for the ‘Outstanding First Authored Paper in Endocrinology Award’ for the year 2012)
  11. Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD (2012) Glucagon-Like Peptide-1 Receptor Agonist, Exendin-4, Regulates Feeding-Associated Neuropeptides in Hypothalamic Neurons in Vivo and in Vitro. Endocrinology 153:2208-22 (This article was selected for the editorial commentary in News and Views, Endocrinology, 2012, 153:2051-3)
  12. Dalvi PS, Nazarians-Armavil A, Tung S, Belsham DD (2011) Immortalized Neurons for the Study of Hypothalamic Function. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 300:R1030-52
  13. Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM (2009) Ciliary neurotrophic factor recruitment of glucagon like peptide-1 mediates neuro-genesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J 23:4256-65
  14. Madadi G, Dalvi PS, Belsham DD (2008) Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. Biochem Biophys Res Commun 376:694-99

BOOK CHAPTERS / BOOKS 

  1. Rahman S, Majumder AA, Kabir R, Haque M, Gupta S, Arafat SMY, Ojeh N, Dalvi PS (2017) "Chapter 5: Cardiovascular Disease and Diabetes: Two Sides of the Same Coin!" Recent Trends in Cardiovascular. ISBN 978-953-51-3328-5. InTech - open science. (http://dx.doi.org/10.5772/intechopen.69038)
  2. Konieczko EM, Dalvi PS, Mattinson CE (2018) Gannon University Human Gross Anatomy Lab Dissector. Gannon University Press (Erie, PA, USA)

CONFERENCE PRESENTATIONS

  1. Helfer G, Nanou S, Dalvi PS, Kantanemni S (2018) Chemerin receptor signalling pathways, trafficking and regulation in the hypothalamus. The 9th International Congress of Neuroendocrinology, Toronto, Canada
  2. Dalvi PS, Chalmers JA, Wheeler MB, Belsham DD (2018) Intranasal Delivery of a microRNA inhibitor to miR-1983 improves insulin sensitivity in mice. The 9th International Congress of Neuroendocrinology, Toronto, Canada
  3. Nanou S, Dalvi PS, Kantanemni S, Helfer G (2017) A central role of the adipokine chemerin in energy balance regulation. The Annual Meeting of the British Society for Neuroendocrinology, Nottingham, UK?
  4. Dalvi PSChalmers JA, Luo V, Han DY, Wellhauser L, Liu Y, Tran DQ, Castel J, Luquet S, Wheeler MB, Belsham DD (2016) High-fat diet induces acute and chronic inflammation in the hypothalamus: Effect of palmitate and TNF-α on appetite-regulating NPY neurons. The Annual Meeting of the British Society for Neuroendocrinology, Glasgow, UK
  5. Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD (2012) Proglucagon Gene Expression is Regulated by Insulin, Leptin and cAMP in Mouse Embryonic and Adult Hypothalamic Neuronal Cells. The 94th Annual Meeting of the Endocrine Society, Houston, USA
  6. Pursr MJ, Dalvi PS, Belsham DD (2011) The effects of ciliary neurotrophic factor on mouse hypothalamic neuropeptides. The 93rd Annual Meeting of the Endocrine Society, Boston
  7. Dalvi PS, Purser MJ, Belsham DD (2010) Effect of exendin-4 on appetite-regulating neuropeptides in the mouse hypothalamic neurons. The 92nd Annual Meeting of the Endocrine Society, San Diego, USA

 

Scholarship/Research

My major research interest is to study the role of inflammation in hypothalamic neurons in development of obesity, central insulin resistance and neurodegenerative disorders using neuronal cell models. My other research interest is to investigate the role of early life nutritional insults (malnutrtion and overnutrition) in the growing global epidemic of chronic metabolic disorders, such as obesity, non-alcoholic fatty liver disease and diabetes.

Service

Member, University Academic Safety Committee, November 2017 – current, Gannon University, Erie, PA.

Member, Risk Management Review Commitee, January - April 2017, Gannon University, Erie, PA.

 

Editorial Board Member, American Research Journal of Anatomy

Editorial Board Member, Global Scientific Research Journal of Anatomy

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