Haverford College, BA in Molecular and Cellular Biology
University of Washington, Ph.D. in Molecular and Cellular Biology; 2005. Glial cells regulate neuromast precursor cells in the zebrafish lateral line.
University of Colorado, Health Science Center - Postdoctoral Fellow, 2006-2008
American Association for the Advancement of Science - Science Policy Fellow, 2008-2010.
Grant, KA, Shadle, M, Andraso, GA. 2012. First report of tubenose goby (Proterorhinus semilunaris) in the eastern Basin of Lake Erie. J. Great Lakes Research http://dx.doi.org/10.1016/j.jglr.2012.09.019
Hernandez-Lagunas L, Powell DR, Law J, Grant KA, Artinger KB. 2011. prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border. Dev Biol 356(2): 496-505.
Grant, K.A., Raible, D.W, Piotrowski, T. 2005. Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line. Neuron 45(1): 69-80.
Lister, J.A., Cooper, C., Nguyen, K., Modrell, M., Grant, K., Raible, D.W. 2006. Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol 290(1): 92-104.
Grant, K.A.*, Hanna-Rose, W.*, Han, M. 2000. sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 hox. Dev Biol 224(2): 496-506. * denotes co-first authors.
My students and I are tackling a few, diverse projects.
1. How is the size of organs are regulated during development? We take a couple approaches to this question.
How is the size of a neuromast determined? Neuromasts are sensory organs in fish. They typically adopt a specific morphology based on their position within the fish. We are trying to discover the genes involved in the patterning of these sense organs.
What genes and cellular processes drive the difference in the size, shape, and the tooth type of the jaw in two closely related species. We are studying the differences in the jaw between different sunfish, pumpkinseeds and bluegills. First we need to understand when the shape of the bone and teeth change; then we can investigate the genetic regulation of those changes.
2. How are stem cells affected by environmental pollutants? Stem cells are integral to developmental processes; however, there is a dearth of infomation regarding how stem cells respond to chemicals in the environment. We are specifically investigating the response of stem cells in the zebrafish lateral line to Lake Erie water and sediment. We hope to extend this project and investigate the affects of specific emerging contaminants.
3. While investigating the lateral line (a sensory organ) in fish that are found locally; Dr. Greg Andraso, Gannon students, and I discovered tubenose goby, an exotic species that is new to this region of Lake Erie. My students are now working to develop molecular techniques to investigate the ecology of the Tubenose goby.